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Rare and common paraoxonase gene variants in amyotrophic lateral sclerosis patients

✍ Scribed by Marka van Blitterswijk; Anna Blokhuis; Michael A. van Es; Paul W.J. van Vught; Paulina A. Rowicka; Helenius J. Schelhaas; Anneke J. van der Kooi; Marianne de Visser; Jan H. Veldink; Leonard H. van den Berg

Book ID
118488395
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
337 KB
Volume
33
Category
Article
ISSN
0197-4580

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## Abstract Three clustered, homologous paraoxonase genes (__PON1__, __PON2,__ and __PON3__) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the __PON__ genes and sporadic amyotrophic lateral sclerosis (ALS). We now re