✦ LIBER ✦

A gene apparently determining the extent of sialylation of lysosomal α-mannosidase in mouse liver

✍ Scribed by Mark Dizik; Rosemary W. Elliott

Book ID: 104784057
Publisher: Springer
Year: 1977
Tongue: English
Weight: 782 KB
Volume: 15
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00484546

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✦ Synopsis

Organ-specific electrophoretic heterogeneity of lysosomal alpha-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal alpha-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.

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