The developmental regulation of the a-fetoprotein (AFP) gene in liver results in high-level expression in the fetus, followed by dramatic transcriptional repression after birth. We have examined the mouse AFP gene for transcriptional control sequences that may be involved in its postnatal repression
✦ LIBER ✦
A silencer regulates the expression of the mouse α-fetoprotein gene in adult liver
✍ Scribed by J. Vacher; S.M. Tilghman
- Book ID
- 113395405
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 77 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0922-3371
No coin nor oath required. For personal study only.
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## Abstract The molecular mechanisms by which mesenchymal cells differentiate into chondrocytes are poorly understood. The cartilage oligomeric matrix protein gene (COMP) encodes a noncollagenous extracellular matrix protein whose expression pattern correlates with chondrocyte differentiation and a