A FURTHER NOTE ON THE SIB-PAIR LINKAGE METHOD
โ Scribed by PENROSE, L. S.
- Book ID
- 115246414
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1946
- Tongue
- English
- Weight
- 258 KB
- Volume
- 13
- Category
- Article
- ISSN
- 2050-1420
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Fulker and Cardon's interval mapping extension of Haseman and Elston's sibโpair linkage method was used to map loci affecting the quantitative phenotypes presented as part of Problem 2, both adjusted and not adjusted for covariates: Q1 was adjusted for age and the environmental factor (
A novel approach to combining data from multiple linked loci is proposed that can provide substantial increases in power over normal two-point linkage analysis or sib-pair analysis, with a substantial saving in computing time over traditional multipoint methods. 1993 Wiley-Liss, Inc.
We used sib-pair linkage analysis as part of an epidemiologic approach to solving Problem 2 of the GAW10 data set of nuclear families. We recoded the quantitative trait Q1 into a dichotomous trait using Q1 $ 40 as the cut-point. In a case-control design of sib-pair analysis, the affected siblings of
For Mendelian disorders, it is usually simple to classify individuals as either affected or unaffected. By contrast, for "complex" phenotypes, the diagnostic boundary of the disorder is often uncertain. This paper explores the following question: to most efficiently detect linkage in such a complex
Model-free sib-pair linkage analysis was used to screen the GAW9 -Problem 1 data set for evidence of linkage of a rare disease to any of 360 highly polymorphic marker loci. Negative regressions nominally significant at the 01 = 0.05 level were obtained for 44 markers; however all of these proved to