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A function of tetrahydropteridines as cofactors for indoleamine 2,3-dioxygenase

✍ Scribed by Morimitsu Nishikimi


Book ID
119405748
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
309 KB
Volume
63
Category
Article
ISSN
0006-291X

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S-Benzylisothiourea 3a was discovered by its ability to inhibit indoleamine-2,3-dioxygenase (IDO) in our screening program. Subsequent optimization of the initial hit 3a lead to the identification of sub-lM inhibitors 3r and 10h, both of which suppressed kynurenine production in A431 cells. Synthesi