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A fraction of beech wood mutagenic in the Salmonella/mammalian microsome assay

โœ Scribed by E. Mohtashamipur; K. Norpoth; B. Hallerberg

Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
457 KB
Volume
58
Category
Article
ISSN
0340-0131

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โœฆ Synopsis

Base-pair substitution mutagens were isolated from the dusts of several untreated samples of beech wood and tested for mutagenicity in the Salmonella/mammalian microsome assay These compounds reverted Salmonella typhimurium his TA 100 in the presence of Aroclor-induced rat 59 These mutagens were found to be toxic to the cells when tested in a histidine-rich medium (complete medium) Mutagenicity of the non-fractionated wood-dust extracts due to the presence of some inhibitory compounds of wood could not be confirmed significantly These inhibitors counteracted the reversion of bacteria when the known mutagens, such as benzo(a)pyrene, aflatoxin B l and ethyl methanesulfonate, were tested The results indicate that beech wood-dust contains mutagenic constituent(s) which may contribute to their assumed tumor bearing effects among woodworkers.

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