Mutagenicity of resin acids identified in pulp and paper mill effluents using the salmonella/mammalian-microsome assay
✍ Scribed by Nestmann, Earle R. ;Lee, E. G.-H. ;Mueller, J. C. ;Douglas, George R.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1979
- Weight
- 354 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0192-2521
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✦ Synopsis
Ten resin acids which have been identified as constituents of pulp and paper mill effluents have been examined for potential mutagenicity in the Salmonella/ mammalian-microsome assay. Only neoabietic acid has been found to be mutagenic. Neoabietic acid showed dose-related increases in mutagenicity in strains TA1535, TAlOO, TA1538, and TA98, but not in strain TA1537. Metabolic activation with a preparation of Aroclor 1254-induced liver homogenate (S9) slightly reduced the mutagenic responses. Negative responses were found for abietic acid, dehydroabietic acid, levopimaric acid, 7-oxodehydroabietic acid, monochlorodehydroabietic acid, dichlorodehydroabietic acid, pimaric acid, isopimaric acid, and sandaracopimaric acid.