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Mutagenicity of organic extracts from canadian drinking water in the salmonella/mammalian-microsome assay

✍ Scribed by Nestmann, Earle R. ;Lebel, Guy L. ;Williams, David T. ;Kowbel, David J.

Publisher: Wiley (John Wiley & Sons)
Year: 1979
Weight: 464 KB
Volume: 1
Category: Article
ISSN: 0192-2521
DOI: 10.1002/em.2860010405

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✦ Synopsis

Organic extracts of chlorinated Ontario drinking water samples have been found to induce mutation and lethality in the Salmonella/mammalianmicrosome histadine reversion assay. Collections of water were made at water treatment plants in five municipalities in June 1978. To determine the reproducibility of the positive mutagenic effects found, a second sampling at the same plants was performed in September 1978. Preparation of extracts involved passing 200 liter samples through XAD-2 resin columns which were eluted with a mixture of hexane and acetone, and the eluent was evaporated to dryness. For those extracts with sufficient organic matter, dose-related increases in mutagenicity were observed. Extracts of untreated water from a river and a well were weakly mutagenic.

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