A formal total synthesis of dactylol
โ Scribed by Leo A. Paquette; Won Hun Ham; David S. Dime
- Book ID
- 104233274
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 247 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
SWll7TlU~: The tetracyclic epoxide 16 was prepared in stereocontrolled fashion from 4,4dimethylcyclohexanone, the key steps being Saegusa ring expansion of its silyl enol ether
๐ SIMILAR VOLUMES
A total synthesis of aplysiatoxin was achieved formally by construction of Kishi's intermediate 13 which carded all the stereochemislry required for the synthesis of aplysiatoxin, from four fragments described in the preceding communication.
## Summay: The key oxindole intermediate (2) which has recently been used in a total synthesis of the alkaloid geneserine, has been prepared by a short, efficient route utilising a radical cyclisation.