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A formal synthesis of thymine polyoxin C

✍ Scribed by Kenn E. Harding; Jack M. Southard


Book ID
108283942
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
215 KB
Volume
16
Category
Article
ISSN
0957-4166

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Asymmetric Synthesis of an Isoxazolidine Nucleoside Analogue of Thymine Polyoxin C. -The first total synthesis of the isoxazolidine amino acid nucleoside analogue (VI) is based on the stereoselective nucleophilic addition of the silyl ketene acetal (II) to the enantiopure N-benzyl nitrone (I) as th