A Fmoc-based submonomeric strategy for the solid phase synthesis of optically pure chiral PNAs
โ Scribed by Tullia Tedeschi; Stefano Sforza; Francesca Maffei; Roberto Corradini; Rosangela Marchelli
- Book ID
- 108285044
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 188 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The acid-mediated cleavage of a synthetic thioxo peptide was monitored using deprotection cocktails with varying concentrations of TFA. Thioxo peptides are acid labile, undergoing cleavage at the amide linkage immediately following the thioamide linkage in the sequence. This acid lability makes Fmoc
Support-bound, Fmoc-protected amines react with aliphatic alcohols in the presence of ADDP, PBu 3 , and DIPEA to yield O-alkyl carbamates. The reaction presumably proceeds via O-alkylation of an intermediate carbamate anion.