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A feasibility study of the SDI test for the evaluation of gastrointestinal cancer sensitivity to anticancer drugs

✍ Scribed by Dr. Masaji Yamauchi; Tetsuya Satta; Akihiro Ito; Tatsuhei Kongo; Hiroshi Takagi


Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
638 KB
Volume
47
Category
Article
ISSN
0022-4790

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## Abstract The P‐glycoprotein (p170, P‐gp) encoded by human __MDR1__ gene functions as a pump to extrude anticancer drugs from cancer cells. Over‐expression of p170 is closely related to primary and induced drug resistance phenotype of tumor cells. Recent studies have demonstrated that expression