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Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study

✍ Scribed by Sandip Dhondiram Gurav; Ravindranath Reddy Gilibili; Sherine Jeniffer; Sanjeev Giri; Nuggehally R Srinivas; Ramesh Mullangi

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
590 KB
Volume
25
Category
Article
ISSN
0269-3879

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Highly sensitive method for the determin
Highly sensitive method for the determination of omeprazole in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study
✍ Shivva Vittal; Ramesh Ganneboina; Buddhadev Layek; Ravi Kumar Trivedi; Kishore K 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 705 KB

## Abstract A highly sensitive, rapid assay method has been developed and validated for the estimation of omeprazole (OPZ) in human plasma with liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive‐ion mode. The assay procedure involves alkalinizatio