✦ LIBER ✦

A fast algorithm for the computation of the plasma concentration time curve and confidence limits in linear pharmacokinetics

✍ Scribed by P.J.A. Lago

Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 531 KB
Volume: 20
Category: Article
ISSN: 0010-4809
DOI: 10.1016/0010-4809(87)90051-6

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✦ Synopsis

An algorithm is developed for the computation of the plasma concentration time curve for a drug administration regime involving fast injection (bolus) and/or continuous infusion. The effect of the pharmacokinetic model parameter variations on the plasma concentration time curve is analyzed and efficient algorithms for the computation of the parameter-induced first-order variation and confidence bounds of the plasma concentration time curve are also presented. The application of the method is illustrated with pharmacokinetic data for the etomidate.

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