Prediction of the possibility of the second peak of drug plasma concentration time curve after iv bolus administration from the standpoint of the traditional multi-compartmental linear pharmacokinetics

Prediction of the possibility of the sec

Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ

✍ Leonid M. Berezhkovskiy 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB

The article considers the problem of determination of organ clearance and the time course of drug plasma concentration using the model for which the drug transit time through the organ is regarded as one of the parameters. The suggested nonsteady state approach to the determination of organ clearanc