In a recent paper,' we reported an equation for the calculation of the fraction of the bioavailable dose remaining in the body at t,,, Fsys,l,,, assuming that the drug follows one-compartment model disposition and first-order absorption. It was shown' that this fraction is solely dependent on the ra
โฆ LIBER โฆ
Fraction of the bioavailable dose remaining in the body at the time of peak plasma concentration in a linear, open, one-compartment model
โ Scribed by P. Macheras; C. Reppas; M. Symillides
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 272 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
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In a recent study, Chen and Pelsorl reevaluated the applicability of the half-life approach in the assessment of the relative extent of drug absorption for bioavailabilityl bioequivalence studies. This approach is based on the comparisons of the truncated areas under the curve (AUCs; that is, AUC, )