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Fraction of the bioavailable dose remaining in the body at the time of peak plasma concentration in a linear, open, one-compartment model

โœ Scribed by P. Macheras; C. Reppas; M. Symillides


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
272 KB
Volume
81
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


Equations for the fraction of bioavailab
โœ Dr P. Macheras; M. Symillides; C. Reppas ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 162 KB ๐Ÿ‘ 2 views

In a recent paper,' we reported an equation for the calculation of the fraction of the bioavailable dose remaining in the body at t,,, Fsys,l,,, assuming that the drug follows one-compartment model disposition and first-order absorption. It was shown' that this fraction is solely dependent on the ra

Estimation of absorption rate constant i
โœ P. Macheras; M. Symillides; C. Reppas ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 315 KB ๐Ÿ‘ 1 views

In a recent study, Chen and Pelsorl reevaluated the applicability of the half-life approach in the assessment of the relative extent of drug absorption for bioavailabilityl bioequivalence studies. This approach is based on the comparisons of the truncated areas under the curve (AUCs; that is, AUC, )