A facile synthesis of α,α,ω,ω-tetrahalo-α,ω-dicarboxylic esters
✍ Scribed by Yoelit Migron; Jochanan Blum; Jacob Bar-Tana
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 273 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4020
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Abstroct: ct,to-Dicarboxylic acid dimethxl esters are easily obtained by ring clcasagc ol ttnitrocycloalkanones. Thus, reaction ol the latter compounds ~vith three cquixalents of potassium persullatc, in methanol and in presence o1 sulfuric acid at 80 °C, provides ct.to-dicarboxxltc acid dimethyl es
## Abstract The efficient synthesis of eight new macrocyclic amides (lactams) __via__ reaction of diesters with diamines under normal dilution conditions is described. The role of intermolecular H‐bond formation and steric hindrance is discussed based on ^1^H‐ and ^15^N‐NMR studies of appropriate m