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Synthesis of α,ω-epoxyaldehydes by hydroformylation of α,ω-epoxyalkenes

✍ Scribed by C Botteghi; M Marchetti; S Paganelli; S Scognamillo


Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
92 KB
Volume
179
Category
Article
ISSN
1381-1169

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An efficient and versatile method for the stereospecific construction of a,v-cisand a,v-trans-disubstituted oxepane skeletons is described. Cyclization of the hydroxy epoxides promoted by a (Bu 3 Sn) 2 O/ Zn(OTf) 2 system proceeded via an S N 2 process and exo mode selectivity regardless of the conf