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A facile synthesis of pyrazole, isoxazole and pyrimidine ortho-dicarboxylic acid derivatives via β-enaminoketoesters

✍ Scribed by Augusto C. Veronese; Rosella Callegari; Carlo F. Morelli; Chiara B. Vicentini


Book ID
108378756
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
629 KB
Volume
53
Category
Article
ISSN
0040-4020

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## 2-Acetylbenzothiazole (1) reacts with dimethylformamide dimethylacetal (DMF-DMA) to afford the enaminone 2. Compound 2 reacts regioselectively with some nitrilimines 5a-d and nitrile oxides 6b-d to afford the novel pyrazole and isoxazole derivatives 11a-d and 12b-d, respectively, which react wi