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A Facile Synthesis of [N1,NH 2 - 15 N 2 ]-, [N3,NH 2 - 15 N 2 ]-, and [N1,N3,NH 2 - 15 N 3 ]-Labeled Adenine

โœ Scribed by Jain, Moti L.; Tsao, Ya-Ping; Ho, Nan-Lu; Cheng, Jya-Wei


Book ID
118279716
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
51 KB
Volume
66
Category
Article
ISSN
0022-3263

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Synthesis of methotrexate-3-15N-2-15NH2.
โœ Joseph I. Degraw; Kenneth J. Ryan; William T. Colwell; John R. P. Arnold; Gordon ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 205 KB ๐Ÿ‘ 1 views

Condensation of guanidine-15N3 with 4-[ N( 2-amino-3-cyano-5-pyrazinylmethyl)-N-methylamino] benzoic acid (1) in refluxing methanol afforded 4amino-4-deoxy-N10-methylpteroic-3-15N-2-15NH2 (2). indicated no label introduction at the pterin N1 position. Coupling of 2. with diethyl L-gluatmate and subs