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A Facile Synthesis of N-Aryl Substituted Piperidones

✍ Scribed by Qian Geng; Hui Zhang; Weiguo Cao; Yali Chen


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
76 KB
Volume
27
Category
Article
ISSN
0256-7660

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✦ Synopsis


Abstract

A general and efficient procedure for the synthesis of N‐aryl‐substituted 4‐piperidones was developed. The two step syntheses proceeded with an overall yield of 60%‐83% using L‐proline as the ligand for the Cu(I)‐catalyzed Ullmann amination followed by subsequent hydrolysis of resulting ketals.


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