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A facile synthesis of ferrocene grafted N-methyl-spiropyrrolidines through 1,3-dipolar cycloaddition of azomethine ylides

✍ Scribed by A.R. Sureshbabu; R. Raghunathan; B.K. Satiskumar

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 646 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.03.175

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✦ Synopsis

One-pot synthesis of novel ferrocene grafted N-methyl-spiropyrrolidines has been accomplished in good yields through a facile 1,3-dipolar cycloaddition reaction of various azomethine ylide derived from ninhydrin and sarcosine with various ferrocene derivatives as dipolarophile. The regiochemical and stereochemical outcome of the cycloaddition reaction is ascertained by X-ray crystallographic studies of one of the cycloadducts.

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