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A Facile Synthesis of Benzofuran Derivatives: A Useful Synthon for Preparation of Trypsin Inhibitor.

โœ Scribed by Haruo Sekizaki; Kunihiko Itoh; Eiko Toyota; Kazutaka Tanizawa

Publisher
John Wiley and Sons
Year
2003
Weight
105 KB
Volume
34
Category
Article
ISSN
0931-7597

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The Use of Carbon Monoxide and Imines as
The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of ฮฑ-Amino Acid Derived Imidazolines
โœ Rania D. Dghaym; Rajiv Dhawan; Bruce A. Arndtsen ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 74 KB ๐Ÿ‘ 2 views

One of the most facile routes to prepare carboxylate-substituted imidazolines is by the palladium-catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core.