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The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines

✍ Scribed by Rania D. Dghaym; Rajiv Dhawan; Bruce A. Arndtsen

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
74 KB
Volume
113
Category
Article
ISSN
0044-8249

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The Use of Carbon Monoxide and Imines as
The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines
✍ Rania D. Dghaym; Rajiv Dhawan; Bruce A. Arndtsen 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 74 KB 👁 2 views

One of the most facile routes to prepare carboxylate-substituted imidazolines is by the palladium-catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core.