The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium-Catalyzed Synthesis of α-Amino Acid Derived Imidazolines

✍ Scribed by Rania D. Dghaym; Rajiv Dhawan; Bruce A. Arndtsen

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 74 KB
• Volume: 40
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20010903)40:17<3228::aid-anie3228>3.0.co;2-q

✦ Synopsis

One of the most facile routes to prepare carboxylate-substituted imidazolines is by the palladium-catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core.