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A facile synthesis of 2,5-diketopiperazines based on isocyanide chemistry

✍ Scribed by Stefano Marcaccini; Roberto Pepino; Ma̱ Cruz Pozo

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
56 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The Ugi four-component condensation (4-CC) between amines 4, aromatic aldehydes 5, chloroacetic acid 6 and isocyanides 7 afforded the expected 4-CC adducts 8 which were cyclised to the title compounds 9 upon treatment with ethanolic KOH under ultrasonication.

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