𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of chirally pure 2,5-disubstituted diketopiperazines derived from trisubstituted phenylalanines

✍ Scribed by Satyavijayan Narasimhan Danthi; Ronald A. Hill

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
818 KB
Volume
34
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Some new chirally pure 2,5‐substituted diketopiperazines were synthesized starting from 2‐methoxybenzyl alcohol. This multistep synthesis proceeds through the enzymatic synthesis of chirally pure amino acids, protection and dipeptide coupling, cyclization of dipeptide ester formates, and nitration of the resulting diketopiperazines.

πŸ“œ SIMILAR VOLUMES

Synthesis of substituted (D)-phenylalani
Synthesis of substituted (D)-phenylalanine derivatives by regioselective reduction of enantiomerically pure cis-2,3-disubstituted aziridines
✍ Jae-Won Chang; Jae Hyun Bae; Seong-Ho Shin; Chan Sun Park; Daeock Choi; Won Koo πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 186 KB

## Various N-(R)-(+)-(tx-methylbenzyl)-(2R,3R )-disubstituted aziridines were prepared by intramolecular cyclization. The regioselective reduction of the ring C(3)-N bond in the presence of (Boc)~O by catalytic hydrogenation with atmospheric pressure of hydrogen provides (D)-phenylalaninol analogu

ChemInform Abstract: Synthesis of Substi
ChemInform Abstract: Synthesis of Substituted (D)-Phenylalanine Derivatives by Regioselective Reduction of Enantiomerically Pure cis-2,3-Disubstituted Aziridines.
✍ Jae-Won Chang; Jae Hyun Bae; Seong-Ho Shin; Chan Sun Park; Daeock Choi; Won Koo πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 29 KB πŸ‘ 2 views

Synthesis of Substituted (D)-Phenylalanine Derivatives by Regioselective Reduction of Enantiomerically Pure cis-2,3-Disubstituted Aziridines. -Intramolecular cyclization of chiral 2-amino-1,3-propanediol derivatives (I) and subsequent regioselective reduction of the resulting cis-2,3disubstituted a

Synthesis of enantiomerically pure (2R,
Synthesis of enantiomerically pure (2R, 5R) disubstituted pyrrolidines from D-mannitol
✍ M. Marzi; P. Minetti; D. Misiti πŸ“‚ Article πŸ“… 1992 πŸ› Elsevier Science 🌐 French βš– 515 KB

Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form. Some commentS and studies regarding pyrrolidine ring closure (key step) are also qorted. Over the last few years, interest in pyrrolidine-type derivatives has grown considerably, from b