Highly stereoselective synthesis of steroidal 2,5-diketopiperazines based on isocyanide chemistry
✍ Scribed by Andrea C. Bruttomesso; Javier Eiras; Javier A. Ramírez; Lydia R. Galagovsky
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- French
- Weight
- 880 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The Ugi four-component condensation (4-CC) between amines 4, aromatic aldehydes 5, chloroacetic acid 6 and isocyanides 7 afforded the expected 4-CC adducts 8 which were cyclised to the title compounds 9 upon treatment with ethanolic KOH under ultrasonication.
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Ahs&act: Tbereactionbetween (E)-cinnamatdehyde(l), ebloroaeeticacid(2), cyclohexyl iaoeyanide (3), andamines 4affordcdtheexpeetcd Ugi4-CCproducta 5,whichwereeasitycyctisedto(E)-1-substituted N-cyclohexyl-2-( l-phenylcllmn-2-yl)4oxoazetidine-2-carboxarnides 6upontxeahnent wifhmetbanolic KOH. O 1997El