The total synthesis of 1-O-alkyl-2-acetyl-3-glyceryl-(2-trimethyl ammoniummethyl)phosphonate, the phosphono analogue of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcho~ne, is described. The phosphonolipid shows much lower activity than the phospholipid stimulating serotonin release from rabbit platel
A facile synthesis of 1-O-alkyl-2-(R)-hydroxypropane-3-phosphonocholine (lyso-phosphono-platelet activating factor)
โ Scribed by Jeffrey D. Schmitt; Andrew B. Nixon; Adalsteinn Emilsson; Larry W. Daniel; Robert L. Wykle
- Book ID
- 107737281
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 465 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0009-3084
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๐ SIMILAR VOLUMES
The chemical synthesis of the amide analogs of 1-O-alkyl-2-O-acet yl-glyceryl-3-O-phosphoryl cholinc as its phosphono analog (phosphono-AGEPC)and 1-O-alkyl-2-O-acetyl-glyceryl-3-Ophosphoryl ethanolamine as its phosphono analog (phosphono-AGEPE) is reported. The intermediate acetamides for the subse
Biologically active l-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines are prepared in good yields from raffish (Hydrolagus colliei) liver oil, an inexpensive natural product, that contains over 70% neutral ether lipids.