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A facile direct nucleophilic synthesis ofO-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) without HPLC purification

✍ Scribed by Fedorova, Olga; Kuznetsova, Olga; Stepanova, Maria; Maleev, Victor; Belokon, Yuri; Wester, Hans-Juergen; Krasikova, Raisa

Book ID: 125364957
Publisher: Springer
Year: 2014
Tongue: English
Weight: 692 KB
Volume: 301
Category: Article
ISSN: 1588-2780
DOI: 10.1007/s10967-014-3121-2

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## Abstract A slightly modified automated commercial synthesis system for preparation of __O__‐(2‐[^18^F]fluoroethyl)‐l‐tyrosine (FET), an amino acid tracer for tumor imaging with positron emission tomography, is described. Direct nucleophilic fluorination of [^18^F]fluoride with 1,2‐di(4‐methylphe