✦ LIBER ✦

A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

✍ Scribed by Yongxin Han; Amélie Roy; André Giroux

Book ID: 104210567
Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 195 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00907-2

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✦ Synopsis

A versatile protocol for the solid-phase synthesis of highly substituted furan derivatives is discussed. This approach employs zincate 1 as the scaold followed by sequential palladium-catalyzed cross-coupling reactions as the C±C bond-formation step. This methodology allows convenient modi®cation of the furan core in three dimensions, giving rise to structurally diverse derivatives with overall good chemical purity and yield.

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