✦ LIBER ✦

Polymer-bound 4-benzylsulfonyl-1-triphenylphosphoranylidene-2-butanone as a tool for the solid-phase synthesis of substituted piperidin-4-one derivatives.

✍ Scribed by Achille Barco; Simonetta Benetti; Carmela De Risi; Paolo Marchetti; Gian P. Pollini; Vinicio Zanirato

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 210 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01650-5

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✦ Synopsis

An efficient method for the construction of 2-substituted-piperidin-4-one derivatives on solid support has been developed using polymer-bound 4-benzylsulfonyl-l-triphenylphosphoranylidene-2-butanone as a convenient precursor for substituted divinyl ketones in the heterocyclization reaction with amines. The resin was released in a recyclable sulfinate form.