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Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P1-argininal derivatives

✍ Scribed by Daniel V. Siev; John A. Gaudette; J.Edward Semple

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 320 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00870-9

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✦ Synopsis

The design, synthesis and application of novel argininal aminals 1 tethered onto AM resin is described. Efficient solid-phase synthesis routes to a wide array of the title derivatives 2 have been implemented using this convenient technology. The resulting Pl-argininal targets serve as useful exploratory scaffolds for serine and cysteine protease inhibitor discovery.

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