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A dihydropyridine carrier system for sustained delivery of 2',3'-dideoxynucleosides to the brain

โœ Scribed by Palomino, Eduardo; Kessel, David; Horwitz, Jerome P.


Book ID
125960837
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
567 KB
Volume
32
Category
Article
ISSN
0022-2623

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1-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl-(E)-5-(2-iodovinyl)uracil (IVFRU) was coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system (CDS) via a cleavable sugar-ester linkage as a site-directed approach to increase diffusion of the parent nucleoside into the central nervo