𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of brain-targeted 5-iodo-, 5-vinyl- and (E)-5-(2-iodovinyl)-2′-deoxyuridines coupled to a dihydropyridine ⇌ pyridinium salt redox chemical delivery system

✍ Scribed by Rakesh Kumar; Gueijun Ji; Leonard I. Wiebe; Edward E. Knaus


Book ID
112129992
Publisher
Journal of Heterocyclic Chemistry
Year
1991
Tongue
English
Weight
444 KB
Volume
28
Category
Article
ISSN
0022-152X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Synthesis of brain-targeted 1-(2-deoxy-2
✍ Kevin W. Morin; Leonard I. Wiebe; Edward E. Knaus 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 615 KB

1-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl-(E)-5-(2-iodovinyl)uracil (IVFRU) was coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system (CDS) via a cleavable sugar-ester linkage as a site-directed approach to increase diffusion of the parent nucleoside into the central nervo