Synthesis of brain-targeted 1-(2-deoxy-2
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Kevin W. Morin; Leonard I. Wiebe; Edward E. Knaus
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Article
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1993
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Elsevier Science
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English
⚖ 615 KB
1-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl-(E)-5-(2-iodovinyl)uracil (IVFRU) was coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system (CDS) via a cleavable sugar-ester linkage as a site-directed approach to increase diffusion of the parent nucleoside into the central nervo