Dopamine (1) was transformed into a lipoidal redox chemical delivery system which crosses the blood brain barrier and is converted to a quaternary ammonium precursor of 1, thus "locking in" this ionized moiety. Systemic administration of this chemical delivery system for 1 increased concentrations o
β¦ LIBER β¦
New systems for the specific delivery and sustained release of dopamine to the brain
β Scribed by Vincenzo Carelli; Felice Liberatore; Luigi Scipione; Mariannina Impicciatore; Elisabetta Barocelli; Mario Cardellini; Gianfabio Giorgioni
- Book ID
- 113276123
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 575 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0168-3659
No coin nor oath required. For personal study only.
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## Abstract **BACKGROUND:** Drug delivery systems (DDS) were designed using insulin as model drug and poly (lacticβcoβglycolic) copolymers (PLGA) as polymeric matrix. The carriers were synthesized by direct selfβassembly of the insulin and the polyester under mild conditions. **RESULTS:** The kind