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Protein instability and immunogenicity: Roadblocks to clinical application of injectable protein delivery systems for sustained release

✍ Scribed by Wim Jiskoot; Theodore W. Randolph; David B. Volkin; C. Russell Middaugh; Christian Schöneich; Gerhard Winter; Wolfgang Friess; Daan J. A. Crommelin; John F. Carpenter

Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
103 KB
Volume
101
Category
Article
ISSN
0022-3549

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PLGA based drug delivery systems (DDS) for the sustained release of insulin: insight into the protein/polyester interactions and the insulin release behavior
✍ Verónica Lassalle; María Luján Ferreira 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 281 KB 👁 1 views

## Abstract **BACKGROUND:** Drug delivery systems (DDS) were designed using insulin as model drug and poly (lactic–co‐glycolic) copolymers (PLGA) as polymeric matrix. The carriers were synthesized by direct self‐assembly of the insulin and the polyester under mild conditions. **RESULTS:** The kind