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A cryptic insertion (17;15) on both chromosomes 17 with lack of PML–RARA expression in a case of atypical acute promyelocytic leukemia

✍ Scribed by Tchinda, J; Volpert, S; Liersch, R; Zühlsdorf, M; Serve, H; Neumann, T; Kennerknecht, I; Berdel, W E; Büchner, T; Horst, J

Book ID
110055677
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
177 KB
Volume
18
Category
Article
ISSN
0887-6924

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D N A studies of the translocation t( 15; 17) in acute promyelocytic leukemia (APL) have shown that the retinoic acid receptor alpha (RARA) gene on chromosorne I7 is juxtaposed to the promyelocytic leukemia (PML) gene on chromosome 15. The PML breakpoints have been mapped to1 3 clusters: bcr I, bcr2

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## Abstract We compared genomic breakpoints at the __PML__ and __RARA__ loci in 23 patients with therapy‐related acute promyelocytic leukemia (t‐APL) and 25 de novo APL cases.Eighteen of 23 t‐APL cases received the topoisomerase II poison mitoxantrone for their primary disorder. DNA breaks were clu