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A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

✍ Scribed by Liu, Yongzhong; Zhang, Pin; Li, Jun; Kulkarni, Ashok B; Perruche, Sylvain; Chen, WanJun

Book ID
109920679
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
550 KB
Volume
9
Category
Article
ISSN
1529-2908

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## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut