Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation
β Scribed by Petra Hoffmann; Tina J. Boeld; Ruediger Eder; Jochen Huehn; Stefan Floess; Georg Wieczorek; Sven Olek; Wolfgang Dietmaier; Reinhard Andreesen; Matthias Edinger
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 563 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0014-2980
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The transcription factor FOXP3 plays a key role in CD4 + CD25 + regulatory T cell function and represents a specific marker for these cells. Despite its strong association with regulatory T cell function, in humans little is known about the frequency of CD4 + CD25 + cells that express FOXP3 protein
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