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Distinct regulatory roles of transforming growth factor-β and interleukin-4 in the development and maintenance of natural and induced CD4+ CD25+ Foxp3+ regulatory T cells

✍ Scribed by Jana Prochazkova; Jan Fric; Katerina Pokorna; Ales Neuwirth; Magdalena Krulova; Alena Zajicova; Vladimir Holan

Book ID
108782533
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
430 KB
Volume
128
Category
Article
ISSN
0019-2805

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Distinct roles of CTLA-4 and TGF-β in CD
Distinct roles of CTLA-4 and TGF-β in CD4+CD25+ regulatory T cell function
✍ Qizhi Tang; Elisa K. Boden; Kammi J. Henriksen; Helene Bour-Jordan; Mingying Bi; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut