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A convergent synthesis of an LTD4 antagonist, RG12525

✍ Scribed by Adam W. Sledeski; Michael K. O'Brien; Larry K. Truesdale

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 206 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02460-4

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✦ Synopsis

An efficient, convergent synthesis of an LTD 4 antagonist, RG12525 (1) has been achieved through the alkylation of the (2-quinolinylmethoxy)phenol (2) with either a triphenylmethyl protected tetrazole synthon (4a) or with a tetrahydropyranyl derivative (4b). Preparation of synthons 4a and 4b, as well as novel preparation of 2 is described.

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