Solid-phase synthesis of amino amides an
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William L Scott; Francisca Delgado; Karen Lobb; Richard S Pottorf; Martin J O'Do
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Article
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2001
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Elsevier Science
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French
β 86 KB
Unnatural amino amides and peptide amides can be synthesized, using solid-phase chemistry, from glycine attached directly (or through an intervening peptide sequence) to a Rink resin. The glycine is converted to an activated benzophenone imine derivative, followed by C-alkylation and hydrolysis. Thi