Convenient synthesis of 1,3-substituted-
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Steven N. Gallicchio; Ian M. Bell
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Article
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2009
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Elsevier Science
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French
โ 493 KB
The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to fu