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Convenient synthesis of 1,3-substituted-6-phenylpiperazin-2-ones

✍ Scribed by Steven N. Gallicchio; Ian M. Bell

Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
493 KB
Volume
50
Category
Article
ISSN
0040-4039

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✦ Synopsis

The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to furnish the desired substituted piperazinones.

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