Enantiospecific synthesis of 6-substituted N-aryl-1,3-oxazin-2-ones
β Scribed by Braj B. Lohray; Sundarababu Baskaran; B. Yadi Reddy; K. Srinivas Rao
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 126 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
β¦ Synopsis
A novel and facile synthesis of 6-substituted chiral N-aryl-l,3-oxazin-2-one derivatives has been achieved starting from readily available (A)-aspartic acid.
π SIMILAR VOLUMES
## Abstract Derivatives of the unknown 2βaminoβ6__H__β1,3βoxazinβ6βone **2** have been synthesized for the first time in two steps and in excellent yields, starting from __N__βcyanocarbonimidates **3a**β**c** and cyanoacetates. The structures of **2a**β**c** are assigned by NMRβspectroscopic method
The convenient preparation of novel 6-phenylpiperazin-2-ones from simple starting materials via a practical two-step procedure is presented. This methodology involves an initial alkylation of 2-bromoacetophenone with an amino ester followed by a one-pot reductive amination and cyclization step to fu
Oxazinones have been synthesised and used as chiral templates in the synthesis of I~substituted aspartic acids. Use of a Bredmvck's reagent/Grigaard/hydrogenation strategy gave c/soxazinones with complete stereoseleetivity, whereas an alkylation strategy, although trans-selective, gave mixtures of i