A convenient synthesis of novel N-dichloroacetyl-1,3-oxazolidine
β Scribed by Fei Ye; Lei Yang; Haitao Li; Ying Fu; Weijun Xu
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 98 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.289
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β¦ Synopsis
Abstract
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A short and efficient route of synthesis and structural characterization of a series of novel Nβdichloroacetylβ1,3βoxazolidine derivatives has been developed. These new compounds characterized of the disubstitution at position 2 by alkyl, cycloalkane, and phenyl were synthesized in good yields via a sequential procedure involving condensation and acylation. All the compounds are characterized by IR, ^1^H NMR, ^13^C NMR, and element analysis. J. Heterocyclic Chem., (2010).
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## Abstract A convenient synthesis of chloramphenicol labelled with carbonβ14 in the dichloroacetyl group at the 1 position is described. It was prepared as part of a 4βstep sequence from [1**β**^14^C] glycine and the product was purified by preparative HPLC. A radiochemical yield of 47% was obtain