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A convenient synthesis of germacyclobutanes

✍ Scribed by Johannes W.F.L. Seetz; Bartholomeus J.J. Van De Heisteeg; Gerrit Schat; Otto S. Akkerman; Friedrich Bickelhaupt

Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
243 KB
Volume
277
Category
Article
ISSN
0022-328X

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## Abstract A convenient synthesis of the antidepressant paroxetine starting from 1‐benzyl‐4‐piperidone (**2**) is reported. A stereoselective reduction resulted in __cis__‐piperidine‐3‐methanol [(**+**)‐**6**]. The reaction between __cis__‐piperidine‐3‐methanol mesylate (**7**) and sesamol led to