A convenient synthesis of bridged azatricyclic anhydrides

✍ Scribed by P. Canonne; M. Akssira; A. Dahdouh; H. Kasmi; M. Boumzebra

• Book ID: 104203875
• Publisher: Elsevier Science
• Year: 1993
• Tongue: French
• Weight: 514 KB
• Volume: 49
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(01)86298-0

✦ Synopsis

Bridged N-protected p-amino acids have been regioselectively prepared from the corresponding bicyclic monoesrers. The subsequent cyclisation by thionyl chloride produced rhe &sired bridged azatricyclic anhydrides which are versatile substrates for the synthesis of dipeptides; they are also converted into oxathymine and oxauracil by a thermal [4+2] cycloreversion.

P. CAN0NNe et al.