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A convenient synthesis of 1′-H-spiro-(indoline-3,4′-piperidine) and its derivatives

✍ Scribed by Jian-Shu Xie; Charles Q Huang; Yan-Yan Fang; Yun-Fei Zhu


Book ID
108282568
Publisher
Elsevier Science
Year
2004
Tongue
French
Weight
136 KB
Volume
60
Category
Article
ISSN
0040-4020

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✍ Jeffrey A. Pfefferkorn; Chulho Choi 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 153 KB

The spirocyclic indoline ring system represents an important scaffold for the discovery of novel therapeutics. Herein, we describe the synthesis of 1,1 0 -H-spiro[indoline-3,3 0 -piperidine] using an intramolecular palladium-catalyzed a-arylation reaction.